Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid.

@article{Meyers2009SynthesisCA,
  title={Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid.},
  author={Ross O. Meyers and Joshua D Lambert and Nicole Hajicek and Alan Pourpak and John A. Kalaitzis and Robert T. Dorr},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 16},
  pages={4752-5}
}
Synthesis of seven semi-synthetic analogs of NDGA is described. An approach to NDGA derivatization is described in which the ortho-phenolic groups are tethered together by one atom, forming a 5-membered heterocyclic ring. The analogs were evaluated for cytotoxicity in four cancer cell lines and compared to NDGA and tetra-O-methyl-NDGA (M4N) (1a). NDGA bis… CONTINUE READING