Synthesis, biological evaluation and structure-activity relationship studies of isoflavene based Mannich bases with potent anti-cancer activity.

@article{Chen2015SynthesisBE,
  title={Synthesis, biological evaluation and structure-activity relationship studies of isoflavene based Mannich bases with potent anti-cancer activity.},
  author={Yilin Chen and Shelley L Cass and Samuel K. Kutty and Eugene Yee and Daniel Shiu Hin Chan and Christopher R Gardner and Orazio Vittorio and Eddy Pasquier and David StC Black and Naresh Kumar},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 22},
  pages={5377-83}
}
Phenoxodiol, an analogue of the isoflavone natural product daidzein, is a potent anti-cancer agent that has been investigated for the treatment of hormone dependent cancers. This molecular scaffold was reacted with different primary amines and secondary amines under different Mannich conditions to yield either benzoxazine or aminomethyl substituted… CONTINUE READING