Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.

@article{Hfling2010SynthesisBE,
  title={Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.},
  author={Sarah B H{\"o}fling and Simone Maschauer and Harald H{\"u}bner and Peter Gmeiner and H-J Wester and Olaf Prante and Markus R Heinrich},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 23},
  pages={6933-7}
}
Radical (18)F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D(3)-selective ligand SH 317 ([(18)F]8). SH 317 has been evaluated as a new PET ligand candidate by in vivo experiments.