Synthesis, biological evaluation and molecular docking studies of novel benzimidazole derivatives

@article{Singh2018SynthesisBE,
  title={Synthesis, biological evaluation and molecular docking studies of novel benzimidazole derivatives},
  author={Gagandeep Singh and Amanjot Singh and Raman K. Verma and Rajiv Mall and Uzma Azeem},
  journal={Computational biology and chemistry},
  year={2018},
  volume={72},
  pages={45-52}
}
A novel series of N-substituted-benzimidazolyl linked para substituted benzylidene based molecules containing three pharmacologically potent hydrogen bonding parts namely; 2,4-thiazolidinedione (TZD: a 2,4-dicarbonyl), diethyl malonate (DEM: a 1,3-diester and an isooxazolidinedione analog) and methyl acetoacetate (MAA: a β-ketoester) (6a-11b) were synthesized and evaluated for in vitro α-glucosidase inhibition. The structure of the novel synthesized compounds was confirmed through the spectral… CONTINUE READING