Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors.

@article{Marco2004SynthesisBE,
  title={Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors.},
  author={J. Marco and C. de los R{\'i}os and Antonio G. Garc{\'i}a and M. Villarroya and M. Carreiras and Carla Martins and A. Eleut{\'e}rio and A. Morreale and M. Orozco and F. J. Luque},
  journal={Bioorganic \& medicinal chemistry},
  year={2004},
  volume={12 9},
  pages={
          2199-218
        }
}
The synthesis and the biological activity of compounds 5-40 as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as modulators of voltage-dependent Ca(2+) channels and nicotinic receptors, are described. These molecules are tacrine analogues, which have been prepared from polyfunctionalized 6-amino-5-cyano-4H-pyrans, 6-amino-5-cyano-pyridines and 5-amino-2-aryl-3-cyano-1,3-oxazoles via Friedländer reaction with selected cycloalkanones. These compounds are… Expand
Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.
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