Synthesis, assembly and structure of gap junction intercellular channels.

@article{Yeager1998SynthesisAA,
  title={Synthesis, assembly and structure of gap junction intercellular channels.},
  author={Mark Yeager and Vinzenz Unger and Matthias M Falk},
  journal={Current opinion in structural biology},
  year={1998},
  volume={8 4},
  pages={517-24}
}
Gap junction membrane channels assemble as dodecameric complexes, in which a hexameric hemichannel (connexon) in one plasma membrane docks end to end with a connexon in the membrane of a closely apposed cell. Steps in the synthesis, assembly and turnover of gap junction channels appear to follow the general secretory pathway for membrane proteins. In addition to homo-oligomeric connexons, different connexin polypeptide subunits can also assemble as hetero-oligomers. The ability to form… CONTINUE READING

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