Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.

@article{Alam2010SynthesisAA,
  title={Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.},
  author={Ozair Alam and Pooja Mullick and Suraj P. Verma and Sadaf Jamal Gilani and Suroor Ahmad Khan and Nadeem A. Siddiqui and Waquar Ahsan},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 6},
  pages={2467-72}
}
A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the… CONTINUE READING
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