Synthesis, activity, and structure--activity relationship studies of novel cationic lipids for DNA transfer.

@article{Byk1998SynthesisAA,
  title={Synthesis, activity, and structure--activity relationship studies of novel cationic lipids for DNA transfer.},
  author={Gerardo Byk and Catherine Dubertret and Virginie Escriou and M. Max GIORDANO Pr{\'e}sident M. Darek CEGLAREK Rapporteu Fr{\'e}d{\'e}ric and Gabrielle Jaslin and Ravi Rangara and Bruno Pitard and Jo{\"e}l Crouzet and Pierre Wils and Bertrand Schwartz and Daniel Scherman},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 2},
  pages={229-35}
}
We have designed and synthesized original cationic lipids for gene delivery. A synthetic method on solid support allowed easy access to unsymmetrically monofunctionalized polyamine building blocks of variable geometries. These polyamine building blocks were introduced into cationic lipids. To optimize the transfection efficiency in the novel series, we have carried out structure-activity relationship studies by introduction of variable-length lipids, of variable-length linkers between lipid and… CONTINUE READING

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