Synthesis, Spectral Characterization and Biological Activity of 1,3,2-dioxaphosphinane Derivatives


Synthesis of a series of new 1, 3, 2dioxaphosphinane derivatives (3a-j) was accomplished. The key step in the synthesis of 3a-j involves the cyclization reaction of tris (hydroxy methyl) nitromethane (1) with P(X)Cl3 (X=S,O) in presence of TEA in THF at 40-45 °C to afford the phosphoryl mono chloride intermediate (2). The intermediate (2) when treated with… (More)

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