Synthesis, Physical Properties, Toxicological Studies and Bioavailability of L‐Pyroglutamic and L‐Glutamic Acid Esters of Paracetamol as Potentially Useful Prodrugs

  title={Synthesis, Physical Properties, Toxicological Studies and Bioavailability of L‐Pyroglutamic and L‐Glutamic Acid Esters of Paracetamol as Potentially Useful Prodrugs},
  author={Ennio Bousquet and Agostino Marrazzo and Giovanni Puglisi and Angelo Spadaro and Salvatore Tirendi},
  journal={Journal of Pharmacy and Pharmacology},
Paracetamol ester prodrugs with L‐pyroglutamic and L‐glutamic acid, biosynthetic precursors of glutathione, have been synthesized to reduce paracetamol hepatotoxicity and improve bioavailability. 
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