Synthesis, Physical Properties, Toxicological Studies and Bioavailability of L‐Pyroglutamic and L‐Glutamic Acid Esters of Paracetamol as Potentially Useful Prodrugs

@article{Bousquet1996SynthesisPP,
  title={Synthesis, Physical Properties, Toxicological Studies and Bioavailability of L‐Pyroglutamic and L‐Glutamic Acid Esters of Paracetamol as Potentially Useful Prodrugs},
  author={E. Bousquet and A. Marrazzo and G. Puglisi and A. Spadaro and S. Tirendi},
  journal={Journal of Pharmacy and Pharmacology},
  year={1996},
  volume={48}
}
Paracetamol ester prodrugs with L‐pyroglutamic and L‐glutamic acid, biosynthetic precursors of glutathione, have been synthesized to reduce paracetamol hepatotoxicity and improve bioavailability. 

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