Synthesis, HPLC measurement and bioavailability of the phenolic amide amkamide.

  title={Synthesis, HPLC measurement and bioavailability of the phenolic amide amkamide.},
  author={J. Park},
  journal={Journal of chromatographic science},
  volume={52 5},
  • J. Park
  • Published 2014
  • Chemistry, Medicine
  • Journal of chromatographic science
Amkamide is a phenolic amide whose analogues were recently reported to have potent mitochondria protective activity, although their bioavailability is still unknown. Therefore, in this study, amkamide was synthesized and confirmed by nuclear magnetic resonance, and a high-performance liquid chromatography (HPLC) method was developed for analyzing the amides in biological samples. HPLC separation was performed on a Nova-Pak C18 column using a gradient condition and a coulometric electrochemical… Expand


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