Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity and apoptosis studies of copper(II) complexes.

@article{Chen2011SynthesisDB,
  title={Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity and apoptosis studies of copper(II) complexes.},
  author={Gong-Jun Chen and Xin Mei Qiao and P Qiao and G Xu and Jing-yuan Xu and Jin-Lei Tian and Wen Gu and Xin Liu and Shi-ping Yan},
  journal={Journal of inorganic biochemistry},
  year={2011},
  volume={105 2},
  pages={119-26}
}
Two new Cu(II) complexes, [Cu(acac)(dpq)Cl] (1) and [Cu(acac)(dppz)Cl] (2) (acac = acetylacetonate, dpq = dipyrido[3,2-d:20,30-f]quinoxaline, dppz = dipyrido[3,2-a:20,30-c] phenazine), have been synthesized and their DNA binding, photo-induced DNA cleavage activity and cell cytotoxicity are studied. The complexes show good binding propensity to calf thymus DNA in the order: 2(dppz) >1(dpq). Furthermore, two complexes exhibit efficient DNA cleavage activity on natural light or UV-A (365 nm… CONTINUE READING