Synthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O′-Diethyl Ester of Ethylenediamine-N,N′-Di-2-(4-Methyl)Pentanoic Acid

@inproceedings{Panteli2016SynthesisCA,
  title={Synthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O′-Diethyl Ester of Ethylenediamine-N,N′-Di-2-(4-Methyl)Pentanoic Acid},
  author={Neboj{\vs}a Panteli{\'c} and Bojana B. Zmejkovski and Dragana Markovi{\'c} and Jelena M. Vuji{\'c} and Tatjana Stanojkovi{\'c} and Tibor J. Sabo and Goran N Kaluđerovi{\'c}},
  year={2016}
}
A novel gold(III) complex, [AuCl2{(S,S)-Et2eddl}]PF6, ((S,S)-Et2eddl = O,O′-diethyl ester of ethylenediamine-N,N′-di-2-(4-methyl)pentanoic acid) was synthesized and characterized by IR, 1D (1H and 13C), and 2D (H,H-COSY and H,H-NOESY) NMR spectroscopy, mass spectrometry, and elemental analysis. Density functional theory calculations confirmed that (R,R)-N,N′ diastereoisomer was energetically the most stable isomer. In vitro antitumor action of ligand precursor [(S,S)-H2Et2eddl]Cl2 and… CONTINUE READING

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SHOWING 1-10 OF 34 REFERENCES

Synthesis, characterization and antitumor properties of two highly cytotoxic ruthenium(III) complexes with bulky triazolopyrimidine ligands

I. Lakomska, M. Fandzloch, T. Muziol, T. Liz, J. Jezierska
  • Dalton Trans
  • 2013

On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy

S. Gómez, D. Maksimović-Ivanić, S. Mijatović, G. N. Kalud̄erović
  • Bioinorg. Chem. Appl
  • 2012
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