Synthesis, Biological Evaluation, and Docking Studies of a Novel Sulfonamido-Based Gallate as Pro-Chondrogenic Agent for the Treatment of Cartilage

@article{Lin2016SynthesisBE,
  title={Synthesis, Biological Evaluation, and Docking Studies of a Novel Sulfonamido-Based Gallate as Pro-Chondrogenic Agent for the Treatment of Cartilage},
  author={Xiao Lin and Ling Chai and Buming Liu and Hailan Chen and Li Zheng and Qin Liu and Cuiwu Lin},
  journal={Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry},
  year={2016},
  volume={22}
}
  • Xiao Lin, Ling Chai, +4 authors Cuiwu Lin
  • Published 2016
  • Chemistry, Medicine
  • Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Gallic acid (GA) and its derivatives are anti-inflammatory agents and are reported to have potent effects on Osteoarthritis (OA) treatment. Nonetheless, it is generally accepted that the therapeutic effect and biocompatibility of GA is much weaker than its esters due to the high hydrophilicity. The therapeutic effect of GA on OA could be improved if certain structural modifications were made to increase its hydrophobicity. In this study, a novel sulfonamido-based gallate was synthesized by… Expand
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SZNTC is revealed as a promising novel agent in the treatment of chondral and osteochondral lesions and can exert chondro-protective effects by promoting cell proliferation and maintaining the phenotype of articular chONDrocytes, as evidenced by improved cell growth and enhanced synthesis of cartilage specific markers. Expand
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JEZ-C is revealed as a promising novel agent in the treatment of chondral and osteochondral lesions and can also exert chondro-protective effects by promoting cell proliferation and maintaining the phenotype of articular chONDrocytes, as evidenced by improved cell growth and enhanced synthesis of cartilage specific markers. Expand
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Results showed that LDQN-C could enhance secretion and synthesis of cartilage extracellular matrix (ECM) by up-regulating expression levels of aggrecan, collagen II and Sox9 genes compared to the GA treated group and control group and might provide a basis for the development of a novel agent for the treatment of articular cartilage defect. Expand
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