Synthesis, Antitubercular Activity and Mechanism of Resistance of Highly Effective Thiacetazone Analogues

@inproceedings{Coxon2013SynthesisAA,
  title={Synthesis, Antitubercular Activity and Mechanism of Resistance of Highly Effective Thiacetazone Analogues},
  author={Geoffrey D. Coxon and D. N. orman Craig and Rosa Milagros Corrales and Emilie Vialla and Laila Gannoun-Zaki and Laurent Kremer},
  booktitle={PloS one},
  year={2013}
}
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis. Thiacetazone (TAC) is an anti-tubercular drug that was formerly used in conjunction with isoniazid, but removed from the antitubercular chemotherapeutic arsenal due to toxic side effects. However, several recent studies have linked the… CONTINUE READING