Synthesis, 470-MHz 1H NMR spectra, and activity of delactonized derivatives of the anticancer drug etoposide.

Abstract

The anticancer drug etoposide (VP 16-213, 1) contains a highly strained trans-fused gamma-lactone. This functionality is readily metabolized to an inactive ring-opened hydroxy acid (2). To prevent this detoxification of the drug and to investigate whether the lactone is essential for drug activity, we synthesized a cyclic ether analogue of etoposide (3) and… (More)

Topics

Cite this paper

@article{Jardine1982Synthesis41, title={Synthesis, 470-MHz 1H NMR spectra, and activity of delactonized derivatives of the anticancer drug etoposide.}, author={Ian Jardine and Robert J Strife and Joseph A Kozlowski}, journal={Journal of medicinal chemistry}, year={1982}, volume={25 9}, pages={1077-81} }