Syntheses of ferulic acid derivatives and their suppressive effects on cyclooxygenase-2 promoter activity.

@article{Hosoda2002SynthesesOF,
  title={Syntheses of ferulic acid derivatives and their suppressive effects on cyclooxygenase-2 promoter activity.},
  author={Asao Hosoda and Yoshihiko Ozaki and Ayumi Kashiwada and Michihiro Mutoh and Koichi Wakabayashi and Kazuhiko Mizuno and Eisaku Nomura and Hisaji Taniguchi},
  journal={Bioorganic & medicinal chemistry},
  year={2002},
  volume={10 4},
  pages={
          1189-96
        }
}
Novel ferulic acid derivatives in which feruloyl groups were attached to the hydroxyl groups of myo-inositol 1,3,5-orthoformate derivatives were synthesized. These feruloyl-myo-inositols suppressed the cyclooxygenase-2 (COX-2) promoter activity in a concentration-dependent manner. Among the examined compounds, compound 9 showed the highest activity. A treatment with 100 microM of compound 9 for 24 h resulted in a 50% decrease of COX-2 promoter activity without marked cytotoxicity. Both the… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

Similar Papers

Loading similar papers…