Syntheses and structure-activity relationships of novel retinoid X receptor agonists.

@article{Hibi1998SynthesesAS,
  title={Syntheses and structure-activity relationships of novel retinoid X receptor agonists.},
  author={S. Hibi and K. Kikuchi and H. Yoshimura and M. Nagai and K. Tai and T. Hida},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 17},
  pages={
          3245-52
        }
}
As part of our studies to develop novel retinoids with increased affinity and selectivity for the retinoid X receptor (RXR) subfamily, we have designed and synthesized a series of (E,E,E)-7-(1,2,3, 4-tetrahydroquinolin-6-yl)-7-alkyl-6-fluoro-3-methylhepta-2, 4, 6-trienoic acid derivatives. These tetrahydroquinolines, generated by introducing a polar N atom into the hydrophobic part of the retinoid skeleton, showed high binding affinity to RXRs. Addition of fluorine at the 6-position of the 2,4… Expand
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