Syntheses and properties of selected derivatives of pyrimido[5,4-e]-1,3-thiazine and pyrimido[4,5-d]pyrimidine.

Abstract

In the reactions of ethyl 4-chloro/tosyloxy/-2-methylpyrimidine-5-carboxylate with differently substituted thioureas, new derivatives of 2,3-dihydro-7-methylpyrimido-[5,4-e]-1,3-thiazine (5-9) and of 7-methyl-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine (12, 13) were obtained. Besides, some derivatives of 4-phenylamino-2-methylpyrimidine-5-carboxylic acid (15-20) were also synthesized. Structure of the compounds was confirmed by spectral analysis (IR, H-NMR) and chemical transformations. In the screening pharmacological examinations some of the compounds revealed analgesic, antiinflammatory and immunosuppressive activity.

Cite this paper

@article{Malinka1989SynthesesAP, title={Syntheses and properties of selected derivatives of pyrimido[5,4-e]-1,3-thiazine and pyrimido[4,5-d]pyrimidine.}, author={Wiesław Malinka and Tomasz Zawisza and Halina Zajac}, journal={Archivum immunologiae et therapiae experimentalis}, year={1989}, volume={37 3-4}, pages={487-97} }