Syntheses and pharmacological activity of N-acyl-substituted imidazolidinethiones and thioimidazolines.


A series of imidazolidinethiones and thioimidazolines was synthesized and tested for their effect on both forced and spontaneous motor activities as well as their ability to raise the convulsion threshold. The N-acyl-substituted 2-p fluorobenzylthioimidazolines were the most active compounds, producing protection against maximal electroshock seizures and… (More)