Syntheses and antibacterial activities of gramicidin S analogs containing L-ornithine in place of L-valine.

@article{Soejima1994SynthesesAA,
  title={Syntheses and antibacterial activities of gramicidin S analogs containing L-ornithine in place of L-valine.},
  author={Yuji Soejima and Akihiro Hashiguchi and Naotaka Izumiya},
  journal={Bioscience, biotechnology, and biochemistry},
  year={1994},
  volume={58 5},
  pages={826-9}
}
A gramicidin S analog ([Orn1,1']GS.4HCl) containing L-ornithine in place of L-valine at the 1,1' positions was synthesized by the conventional solution method in order to examine whether this analog had antibacterial activity toward Gram-negative bacteria. In the synthesis of [Orn1,1']GS.4HCl, two intermediate analogs ([Orn1,1', Orn(For)2,2']GS.2HCl and… CONTINUE READING