Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity.

@article{Shin2004SynthesesAA,
  title={Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity.},
  author={D Y Shin and Sun Nam Kim and Jung-Hyun Chae and Soon-Sil Hyun and S K Seo and Yong-Sil Lee and Kwang-Ok Lee and Seok-Ho Kim and Yun-Sang Lee and Jae Min Jeong and Nam-Song Choi and Young-Ger Suh},
  journal={Bioorganic & medicinal chemistry letters},
  year={2004},
  volume={14 17},
  pages={4519-23}
}
Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.