Syntheses and activities of some bactobolin derivatives.


Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimethylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus. 


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@article{Nishimura1992SynthesesAA, title={Syntheses and activities of some bactobolin derivatives.}, author={Yukio Nishimura and Seiji Kondo and T Takeuchi}, journal={The Journal of antibiotics}, year={1992}, volume={45 5}, pages={735-41} }