Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

Abstract

UNC-13-Munc13s have a central function in synaptic-vesicle priming through their MUN domains. However, it is unclear whether this function arises from the ability of the MUN domain to mediate the transition from the Munc18-1–closed syntaxin-1 complex to the SNARE complex in vitro. The crystal structure of the rat Munc13-1 MUN domain now reveals an elongated… (More)
DOI: 10.1038/nsmb.3038

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@article{Yang2015SyntaxinOB, title={Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming}, author={Xiaoyu Yang and Shen Wang and Y C Sheng and Mingshu Zhang and Wenjuan Zou and Li-jie Wu and Lijun Kang and Josep Rizo and Rongguang Zhang and Tao Xu and Cong Ma}, journal={Nature Structural &Molecular Biology}, year={2015}, volume={22}, pages={547-554} }