Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents.

@article{Naren2000Syntaxin1I,
  title={Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents.},
  author={Anjaparavanda P Naren and Anke Di and Estelle Cormet-Boyaka and Prosper N Boyaka and Jerry R. Mcghee and Weihong Zhou and Kimio Akagawa and Takashi Fujiwara and Ulrich H. Thome and John F. Engelhardt and Deborah J. Nelson and Kevin L. Kirk},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={105 3},
  pages={377-86}
}
The CFTR Cl(-) channel controls salt and water transport across epithelial tissues. Previously, we showed that CFTR-mediated Cl(-) currents in the Xenopus oocyte expression system are inhibited by syntaxin 1A, a component of the membrane trafficking machinery. This negative modulation of CFTR function can be reversed by soluble syntaxin 1A peptides and by the syntaxin 1A binding protein, Munc-18. In the present study, we determined whether syntaxin 1A is expressed in native epithelial tissues… CONTINUE READING