Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis.

@article{Gao2008SynoviolinPI,
  title={Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis.},
  author={Beixue Gao and Sang-Myeong Lee and An Qing Chen and Jinping Zhang and Donna D. Zhang and Krishnaswamy Kannan and Robert A. Ortmann and Deyu Fang},
  journal={EMBO reports},
  year={2008},
  volume={9 5},
  pages={
          480-5
        }
}
The E3 ubiquitin ligase synoviolin (SYVN1) functions as an anti-apoptotic factor that is responsible for the outgrowth of synovial cells during the development of rheumatoid arthritis. The molecular mechanisms underlying SYVN1 regulation of cell death are largely unknown. Here, we report that elevated SYVN1 expression correlates with decreased levels of the protein inositol-requiring enzyme 1 (IRE1)-a pro-apoptotic factor in the endoplasmic reticulum (ER)-stress-induced apoptosis pathway-in… CONTINUE READING
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