Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis.

@article{Cunnane2001SynovialTP,
  title={Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis.},
  author={Gaye Cunnane and Oliver FitzGerald and Klaus Hummel and Peter P Youssef and Renate Erika Gay and S. Kirsten Gay and Barry Bresnihan},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 8},
  pages={1744-53}
}
OBJECTIVE To relate the expression of proteases in the lining and sublining layers of the synovial membrane to the rate of joint damage during 1 year in patients with early inflammatory arthritis. METHODS Samples of synovial membrane were obtained by closed-needle biopsy or needle arthroscopy from inflamed knees of 20 patients with early inflammatory polyarthritis (mean disease duration 9.6 months, range 2 weeks to 18 months). Expression of matrix metalloproteinase 1 (MMP-1), cathepsin B (CB… CONTINUE READING