Synovial sarcoma: defining features and diagnostic evolution.

  title={Synovial sarcoma: defining features and diagnostic evolution.},
  author={Khin Thway and Cyril Fisher},
  journal={Annals of diagnostic pathology},
  volume={18 6},
Synovial sarcoma (SS) is a malignant mesenchymal neoplasm with variable epithelial differentiation, with a propensity to occur in young adults and which can arise at almost any site. It is generally viewed and treated as a high-grade sarcoma. As one of the first sarcomas to be defined by the presence of a specific chromosomal translocation leading to the production of the SS18-SSX fusion oncogene, it is perhaps the archetypal "translocation-associated sarcoma," and its translocation remains… CONTINUE READING
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