Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers.

@article{Bresnihan2007SynovialMA,
  title={Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers.},
  author={Barry Bresnihan and Dani{\"e}lle M. Gerlag and Terence Rooney and Tom J. M. Smeets and Carla Ann Wijbrandts and David B. Boyle and Oliver M Fitzgerald and Bruce W. Kirkham and Iain B. Mcinnes and MaryD. Smith and Ann-Kristin Ulfgren and Douglas J Veale and Paul Peter Tak},
  journal={The Journal of rheumatology},
  year={2007},
  volume={34 3},
  pages={
          620-2
        }
}
Successive studies from one academic center (Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands) have consistently suggested that synovial tissue expression of sublining macrophages may be a biomarker of clinical response to therapeutic intervention in rheumatoid arthritis (RA) clinical trials. A proof-of-concept, randomized clinical trial was completed at a second academic center (St. Vincent's University Hospital, Dublin, Ireland), and the relationship between the… CONTINUE READING

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