Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis.

@article{Firestein1994SynovialIR,
  title={Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis.},
  author={Gary S. Firestein and David L. Boyle and C U Yu and Margaret Paine and T D Whisenand and Nathan J. Zvaifler and William P. Arend},
  journal={Arthritis and rheumatism},
  year={1994},
  volume={37 5},
  pages={644-52}
}
OBJECTIVE To quantify interleukin-1 receptor antagonist (IL-1ra) and IL-1 production and gene expression by rheumatoid arthritis (RA) synovial tissue (ST) cells. METHODS IL-1 alpha, IL-1 beta, and IL-1ra protein levels were measured by enzyme-linked immunosorbent assay in fresh and cultured ST cells, purified synovial macrophages, and fibroblast-like synoviocytes (FLS). The relative expression of the secreted form of IL-1ra (sIL-1ra) and the alternatively spliced intracellular form (icIL-1ra… CONTINUE READING