Synovial fluid-derived mesenchymal stem cells increase after intra-articular ligament injury in humans.

@article{Morito2008SynovialFM,
  title={Synovial fluid-derived mesenchymal stem cells increase after intra-articular ligament injury in humans.},
  author={Toshiyuki Morito and Takeshi Muneta and Kenji Hara and Young-Jin Ju and Tomoyuki Mochizuki and H Makino and Akihiro Umezawa and Ichiro Sekiya},
  journal={Rheumatology},
  year={2008},
  volume={47 8},
  pages={
          1137-43
        }
}
OBJECTIVE The existence of mesenchymal stem cells (MSCs) in SF was previously reported. However, the behaviour and properties of MSCs derived from SF have not been fully elucidated. METHODS Human SFs were obtained from 19 knee joints with anterior cruciate ligament injury around the time of reconstruction surgery, and from three healthy volunteers. SF was plated, cultured and examined for colony-forming number, in vitro differentiation, surface epitopes and gene profiles. Also, rabbit… Expand
Synovial Fluid Mesenchymal Stem Cells for Knee Arthritis and Cartilage Defects: A Review of the Literature.
TLDR
Interestingly, SF-MSC population has shown to increase exponentially in patients with joint injury or disease, pointing to a potential use as a biomarker or as a treatment of some orthopaedic disorders. Expand
Synovial fluid-derived mesenchymal cells have non-inferior chondrogenic potential and can be utilized for regenerative therapy as substitute for synovium-derived cells.
TLDR
MSC derived from synovial fluid could be considered an attractive cell source for cartilage regenerative therapy as a substitute for Syn-MSC, and developing these cells for clinical application may greatly benefit patients undergoing autologous MSC transplantation therapy. Expand
In vitro and in vivo potentialities for cartilage repair from human advanced knee osteoarthritis synovial fluid-derived mesenchymal stem cells
TLDR
Advanced OA SF-MSCs seem better candidates for cell-based constructs conceived for cartilage defects rather than intra-articular injections for diffuse OA. Expand
Mesenchymal Stem Cells in Synovial Fluid Increase After Meniscus Injury
TLDR
The current human study and previous animal studies suggest the possibility that mesenchymal stem cells in synovial fluid increase after meniscus injury contributing to spontaneousMeniscus healing. Expand
Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis
  • I. Sekiya, M. Ojima, +8 authors T. Muneta
  • Medicine
  • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2012
TLDR
The MSC number in the SF was hardly noticed in normal volunteers, but it increased in accordance with the grading of osteoarthritis, and the morphology and gene profiles in SF MSCs were more similar to those in SYN M SCs than in BM MSCS. Expand
Characterization of mesenchymal stem cells derived from the equine synovial fluid and membrane
TLDR
The results suggested that the SF and SM are promising sources of stem cells with satisfactory characteristics of growth and gene expression that can be used in equine regenerative medicine. Expand
Therapeutic potential of autologous mesenchymal stem cells derived from synovial fluid in patients with degenerative arthritis
TLDR
It is demonstrated that SFMSCs from OA-patients might provide therapeutic options for RA and OA, and have the capacity to secrete immunomodulating factors involved in the therapy of rheumatoid arthritis. Expand
Post injury changes in the properties of mesenchymal stem cells derived from human anterior cruciate ligaments
TLDR
The results suggest that colony-forming and differentiation potential decrease over time, and it is important to consider changes in properties of MSCs and use ACL tissue in the acute phase of rupture when biological manipulation is required. Expand
EQUESTRIAN SYNOVIAL FLUID MESENCHYMAL STEM CELLS, A POTENTIAL EXPERIMENTAL MODEL FOR OSTEOARTICULAR THERAPIES
Mesenchymal stem cells (MSCs) therapy has become widely used to treat degenerative diseases. There are various tissue specific sources of stem cells with different therapeutic applications, thereforeExpand
Age-Related Alterations Affecting the Chondrogenic Differentiation of Synovial Fluid Mesenchymal Stromal Cells in an Equine Model
TLDR
The results showed a reduction in cell proliferation correlated with age and the presence of age- related tetraploid cells, which highlighted the influence of aging on MSCs’ characteristics and ability to differentiate towards chondrogenic differentiation and emphasize the importance of considering age-related alterations of MSC’s in clinical applications. Expand
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