Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition.

@article{Zhu2006SynovialAT,
  title={Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition.},
  author={Lingqiao Zhu and Fang Ji and Yuan Wang and Yi Zhang and Qiang Liu and Jingwu Z. Zhang and Kouji Matsushima and Qi Cao and Yanyun Zhang},
  journal={Journal of immunology},
  year={2006},
  volume={177 11},
  pages={8226-33}
}
A hallmark of T cell-mediated autoimmunity is the persistence of autoreactive T cells. However, it remains to elucidate the manner in which synovial T cells are sustained in patients with rheumatoid arthritis (RA). We found that dendritic cells (DC) and tissues from the synovial joints of RA patients expressed higher levels of IDO than DC from healthy donors. Interestingly, T cells derived from the joint synovial fluid (SF) of RA patients proliferated in response to either autologous or… CONTINUE READING