Synonymous codon usage in Escherichia coli: selection for translational accuracy.

@article{Stoletzki2007SynonymousCU,
  title={Synonymous codon usage in Escherichia coli: selection for translational accuracy.},
  author={N. Stoletzki and Adam Eyre-Walker},
  journal={Molecular biology and evolution},
  year={2007},
  volume={24 2},
  pages={374-81}
}
In many organisms, selection acts on synonymous codons to improve translation. However, the precise basis of this selection remains unclear in the majority of species. Selection could be acting to maximize the speed of elongation, to minimize the costs of proofreading, or to maximize the accuracy of translation. Using several data sets, we find evidence that codon use in Escherichia coli is biased to reduce the costs of both missense and nonsense translational errors. Highly conserved sites and… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS