Synonymous and nonsynonymous rate variation in nuclear genes of mammals

@article{Yang2009SynonymousAN,
  title={Synonymous and nonsynonymous rate variation in nuclear genes of mammals},
  author={Ziheng Yang and Rasmus Nielsen},
  journal={Journal of Molecular Evolution},
  year={2009},
  volume={46},
  pages={409-418}
}
A maximum likelihood approach was used to estimate the synonymous and nonsynonymous substitution rates in 48 nuclear genes from primates, artiodactyls, and rodents. A codon-substitution model was assumed, which accounts for the genetic code structure, transition/transversion bias, and base frequency biases at codon positions. Likelihood ratio tests were applied to test the constancy of nonsynonymous to synonymous rate ratios among branches (evolutionary lineages). It is found that at 22 of the… 
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448 Citations

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