Synonymous Virus Genome Recoding as a Tool to Impact Viral Fitness.

  title={Synonymous Virus Genome Recoding as a Tool to Impact Viral Fitness.},
  author={Miguel {\'A}ngel Mart{\'i}nez and Ana Jordan-Paiz and Sandra Franco and Mar{\'i}a Nevot},
  journal={Trends in microbiology},
  volume={24 2},
Synthetic genome recoding is a novel method of generating viruses with altered phenotypes, whereby many synonymous mutations are introduced into the protein coding region of the virus genome without altering the encoded proteins. Virus genome recoding with large numbers of slightly deleterious mutations has produced attenuated forms of several RNA viruses. Virus genome recoding can also aid in investigating virus interactions with innate immune responses, identifying functional virus genome… CONTINUE READING
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