Syngeneic thyroglobulin is immunogenic in good responder mice.

  title={Syngeneic thyroglobulin is immunogenic in good responder mice.},
  author={M Elrehewy and Yi-chi M. Kong and Alvaro A. Giraldo and Noel R. Rose},
  journal={European journal of immunology},
  volume={11 2},
Mouse thyroglobulin (MTg) or thyroid extract (TE) was given repeatedly to good responder C3H/Anf (H-2k) and poor responder BALB/c (H-2d) mice in the absence of adjuvant. Anti-MTg antibodies reached high levels in good responder mice given high doses of thyroid antigen. To eliminate stimulation by alloantigenic determinants and reduce the chance of denaturation. TE from syngeneic mice was prepared freshly each week and injected into good and poor responder strains. Again, significant antibody… CONTINUE READING

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