Syngeneic bone marrow transplantation eliminates V beta 8.2 T lymphocytes from the spinal cord of Lewis rats with experimental allergic encephalomyelitis.

@article{Burt1995SyngeneicBM,
  title={Syngeneic bone marrow transplantation eliminates V beta 8.2 T lymphocytes from the spinal cord of Lewis rats with experimental allergic encephalomyelitis.},
  author={R K Burt and W H Burns and Peter P Ruvolo and Andrew B. Fischer and C H Shiao and Ant{\^o}nio Fernando de Paula Costa Guimar{\~a}es and J Barrett and Alexander Hess},
  journal={Journal of neuroscience research},
  year={1995},
  volume={41 4},
  pages={526-31}
}
Experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), is a paralytic disease of the central nervous system (CNS) mediated by T-lymphocytes reactive to myelin basic protein (MBP). Lewis rats actively immunized with fragment 68 to 82 of guinea pig MBP develop a monophasic disease with spontaneous recovery. Lymphocyte recognition of the primary encephalitogenic sequence of MBP (fragment 68 to 82) is V beta 8.2 T cell receptor (TCR) skewed [1-3]. Lewis rats in… CONTINUE READING

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