Synexin and GTP increase surfactant secretion in permeabilized alveolar type II cells.

@article{Chander2001SynexinAG,
  title={Synexin and GTP increase surfactant secretion in permeabilized alveolar type II cells.},
  author={Avinash Chander and Nilkantha Sen and A Robert Spitzer},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 5},
  pages={L991-8}
}
We have previously suggested that synexin (annexin VII), a Ca(2+)-dependent phospholipid binding protein, may have a role in surfactant secretion, since it promotes membrane fusion between isolated lamellar bodies (the surfactant-containing organelles) and plasma membranes. In this study, we investigated whether exogenous synexin can augment surfactant phosphatidylcholine (PC) secretion in synexin-deficient lung epithelial type II cells. Isolated rat type II cells were cultured for 20-22 h with… CONTINUE READING
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