Synergy of sibutramine and low-dose leptin in treatment of diet-induced obesity in rats.

@article{Boozer2001SynergyOS,
  title={Synergy of sibutramine and low-dose leptin in treatment of diet-induced obesity in rats.},
  author={Carol N. Boozer and Rudolph L. Leibel and Robert J Love and Ming Chuan Cha and Louis J. Aronne},
  journal={Metabolism: clinical and experimental},
  year={2001},
  volume={50 8},
  pages={889-93}
}
Tachyphylaxis to the effects of anorexigenic agents, such as sibutramine (S), may be due, in part, to counterregulatory decreases in energy expenditure (EE) and increases in hunger that result from reduced circulating leptin (L) due to loss of body fat and lowered L production/adipocyte. The present study was conducted to test the hypothesis that L administered at low doses sufficient to restore ambient L to preweight loss concentrations would enhance the intercurrent efficacy of S by reducing… CONTINUE READING