Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer.

  title={Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer.},
  author={Grit S. Herter-Sprie and Syohei Koyama and Houari Korideck and Josephine Hai and Jiehui Deng and Yvonne Y. Li and Kevin A. Buczkowski and Aaron K. Grant and Soumya Ullas and Kevin Rhee and Jillian D Cavanaugh and Neermala Poudel Neupane and Camilla Laulund Christensen and Jan M. Herter and G. Mike Makrigiorgos and Frank Stephen Hodi and Gordon J Freeman and Glenn Dranoff and Peter S. Hammerman and Alec C. Kimmelman and Kwok-kin Wong},
  journal={JCI insight},
  volume={1 9},
Radiation therapy (RT), a critical modality in the treatment of lung cancer, induces direct tumor cell death and augments tumor-specific immunity. However, despite initial tumor control, most patients suffer from locoregional relapse and/or metastatic disease following RT. The use of immunotherapy in non-small-cell lung cancer (NSCLC) could potentially change this outcome by enhancing the effects of RT. Here, we report significant (up to 70% volume reduction of the target lesion) and durable… CONTINUE READING
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