Synergy of human recombinant interleukin 1 with interleukin 2 in the generation of lymphokine-activated killer cells.

@article{Crump1989SynergyOH,
  title={Synergy of human recombinant interleukin 1 with interleukin 2 in the generation of lymphokine-activated killer cells.},
  author={William L. Crump and Laurie B. Owen-Schaub and Elizabeth Ann Grimm},
  journal={Cancer research},
  year={1989},
  volume={49 1},
  pages={149-53}
}
Peripheral blood mononuclear cells cultured in vitro with interleukin 2 (IL-2) become cytolytic towards both autologous and allogeneic tumor cells. We report here that IL-1 synergizes with IL-2 in serum-free conditions to produce increased (1.3-286-fold) lymphokine-activated killer (LAK) activity. The most dramatic synergy is seen with low IL-2 concentrations (10 U/ml, 222 pM) and 50-250 U/ml IL-1 alpha or beta. Kinetics of addition experiments demonstrate a specific requirement for IL-1 at or… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…