Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C

@inproceedings{Xiao2015SynergyOE,
  title={Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C},
  author={Fei Xiao and Isabel Fofana and Christine Thumann and Laurent Mailly and Roxane Alles and Eric Robinet and N Meyer and M Frances Schaeffer and François Habersetzer and Michel Doff{\"o}el and Pieter Leyssen and Johan Neyts and Mirjam B. Zeisel and Thomas F Baumert},
  booktitle={Gut},
  year={2015}
}
OBJECTIVE Although direct-acting antiviral agents (DAAs) have markedly improved the outcome of treatment in chronic HCV infection, there continues to be an unmet medical need for improved therapies in difficult-to-treat patients as well as liver graft infection. Viral entry is a promising target for antiviral therapy. DESIGN Aiming to explore the role of entry inhibitors for future clinical development, we investigated the antiviral efficacy and toxicity of entry inhibitors in combination… CONTINUE READING
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