Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.

@article{Nakahira2002SynergyOI,
  title={Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.},
  author={Masakiyo Nakahira and H Ahn and W R Park and Ping Gao and Michio Tomura and Cheung-Seog Park and Toshiyuki Hamaoka and Tsunetaka Ohta and Masashi Kurimoto and Hiromi Fujiwara},
  journal={Journal of immunology},
  year={2002},
  volume={168 3},
  pages={1146-53}
}
IL-12 and IL-18 synergistically enhance IFN-gamma mRNA transcription by activating STAT4 and AP-1, respectively. However, it is still unknown how STAT4/AP-1 elicit IFN-gamma promoter activation. Using an IL-12/IL-18-responsive T cell clone, we investigated the mechanisms underlying synergistic enhancement of IFN-gamma mRNA expression induced by these two cytokines. Synergy was observed in a reporter gene assay using an IFN-gamma promoter fragment that binds AP-1, but not STAT4. An increase in c… CONTINUE READING

From This Paper

Topics from this paper.
93 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 93 extracted citations

Similar Papers

Loading similar papers…