Synergy between the C 2 allele of transferrin and the C 282 Y allele of the haemochromatosis gene ( HFE ) as risk factors for developing Alzheimer ’ s disease

@inproceedings{Robson2004SynergyBT,
  title={Synergy between the C 2 allele of transferrin and the C 282 Y allele of the haemochromatosis gene ( HFE ) as risk factors for developing Alzheimer ’ s disease},
  author={Kathryn Robson and Donald J. Lehmann and Victoria L C Wimhurst and Karen J Livesey and Marc I. Combrinck and - ATMerryweather and Clarke and Donald R. Warden},
  year={2004}
}
Background: There is evidence that iron may play a role in the pathology of Alzheimer’s disease (AD). There may be genetic factors that contribute to iron deposition resulting in tissue damage thus exacerbating AD. Methods: We have genotyped 269 healthy elderly controls, 191 cases with definite or probable AD, and 69 with mild cognitive impairment (MCI) from the OPTIMA cohort. Results: We have examined the interaction between the C2 variant of the transferrin (TF) gene and the C282Y allele of… CONTINUE READING
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A population - based study of the effect of the HFE C 282 Y and H 63 D mutations on iron metabolism

  • OT Njajou, JJ Houwing-Duistermaat, +6 authors CM vanDuijn
  • Eur J Hum Genet
  • 2003

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