Corpus ID: 7309409

Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.

  title={Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.},
  author={S. Sell and J. M. Hunt and H. Dunsford and F. Chisari},
  journal={Cancer research},
  volume={51 4},
  • S. Sell, J. M. Hunt, +1 author F. Chisari
  • Published 1991
  • Biology, Medicine
  • Cancer research
  • Exposure of female hepatitis B virus transgenic mice of lineage 50-4, which display liver injury secondary to overexpression of the gene for the large envelope polypeptide of hepatitis B virus, to the hepatocarcinogens aflatoxin and diethylnitrosamine produced more rapid and extensive evidence of nodule formation and oval cell proliferation, as well as the development of adenomas and primary hepatocellular carcinomas, than was seen in transgenic mice not exposed to carcinogens. Adult mice are… CONTINUE READING
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