Synergy between a plasminogen cascade and MMP-9 in autoimmune disease.

  title={Synergy between a plasminogen cascade and MMP-9 in autoimmune disease.},
  author={Zhi Liu and Ning Li and Luis A Diaz and Michael E Shipley and Robert M. Senior and Zena Werb},
  journal={The Journal of clinical investigation},
  volume={115 4},
Extracellular proteolysis by the plasminogen/plasmin (Plg/plasmin) system and MMPs is required for tissue injury in autoimmune and inflammatory diseases. We demonstrate that a Plg cascade synergizes with MMP-9/gelatinase B in vivo during dermal-epidermal separation in an experimental model of bullous pemphigoid (BP), an autoimmune disease. BP was induced in mice by antibodies to the hemidesmosomal antigen BP180. Mice deficient in MMP-9 were resistant to experimental BP, while mice deficient in… CONTINUE READING
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