Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.

  title={Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.},
  author={Sandrine Sander and Dinis Pedro Calado and Lakshmi Srinivasan and Karl Koechert and Baochun Zhang and Maciej Rosolowski and Scott J Rodig and Karlheinz Holzmann and Stephan Stilgenbauer and Reiner Siebert and Lars Bullinger and K. Rajewsky},
  journal={Cancer cell},
  volume={22 2},
In Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic properties of c-MYC must be counterbalanced. Predicting that survival signals would be delivered by phosphoinositide-3-kinase (PI3K), a major survival determinant in mature B cells, we indeed found that combining constitutive c-MYC expression and PI3K activity in germinal center B cells of the mouse led to BL-like tumors, which fully phenocopy human BL with regard to histology, surface and other markers, and… CONTINUE READING
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