Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.

@article{Sander2012SynergyBP,
  title={Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.},
  author={Sandrine Sander and Dinis Pedro Calado and Lakshmi Srinivasan and Karl Koechert and Baochun Zhang and Maciej Rosolowski and Scott J. Rodig and Karlheinz Holzmann and Stephan Stilgenbauer and Reiner Siebert and Lars Bullinger and Klaus Rajewsky},
  journal={Cancer cell},
  year={2012},
  volume={22 2},
  pages={
          167-79
        }
}
  • Sandrine Sander, Dinis Pedro Calado, +9 authors Klaus Rajewsky
  • Published 2012
  • Medicine, Biology
  • Cancer cell
  • In Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic properties of c-MYC must be counterbalanced. Predicting that survival signals would be delivered by phosphoinositide-3-kinase (PI3K), a major survival determinant in mature B cells, we indeed found that combining constitutive c-MYC expression and PI3K activity in germinal center B cells of the mouse led to BL-like tumors, which fully phenocopy human BL with regard to histology, surface and other markers, and… CONTINUE READING

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