Synergy between A 2 B Adenosine Receptors and Hypoxia in Activating Human Lung Fibroblasts

@inproceedings{Zhong2004SynergyBA,
  title={Synergy between A 2 B Adenosine Receptors and Hypoxia in Activating Human Lung Fibroblasts},
  author={Hongyan Zhong and Luiz Belardinelli and Tenning Maa and Dewan Zeng},
  year={2004}
}
Chronic inflammatory airway diseases such as asthma, COPD and pulmonary fibrosis are associated with sub-epithelial fibroblast activation, myofibroblast hyperplasia, hypoxia and increase in interstitial adenosine concentrations. The goal of this study was to determine the effect of adenosine and its receptors on activation of human lung fibroblasts (HLFs) under normoxia (21% O2) and hypoxia (5% O2). Under the normoxic condition, adenosine and its stable analog, NECA, via activation of A2B… CONTINUE READING
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