Synergistic transcriptional activation by one regulatory protein in response to two metabolites.

@article{Bundy2002SynergisticTA,
  title={Synergistic transcriptional activation by one regulatory protein in response to two metabolites.},
  author={Becky M Bundy and Lauren S Collier and Timothy R. Hoover and Ellen L Neidle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 11},
  pages={7693-8}
}
BenM is a LysR-type bacterial transcriptional regulator that controls aromatic compound degradation in Acinetobacter sp. ADP1. Here, in vitro transcription assays demonstrated that two metabolites of aromatic compound catabolism, benzoate and cis,cis-muconate, act synergistically to activate gene expression. The level of BenM-regulated benA transcription was significantly higher in response to both compounds than the combined levels due to each alone. These compounds also were more effective… CONTINUE READING

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