Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells.

@article{JimnezLpez2008SynergisticTI,
  title={Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells.},
  author={Jos{\'e} M. Jim{\'e}nez-L{\'o}pez and Defeng Wu and Arthur I. Cederbaum},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2008},
  volume={22 1},
  pages={106-15}
}
TNF-alpha, GSH depletion and CYP2E1 are factors that play an important role in alcoholic liver disease. Activation of NF-kappaB prevents hepatocyte damage caused by TNF-alpha. This work describes the effect of NF-kappaB inhibition on toxicities caused by GSH depletion or arachidonic acid (AA) treatment in liver cells, and evaluates the possible influence of CYP2E1 overexpression. Cells were exposed to the NF-kappaB inhibitor BAY11-7082, in the absence or presence of l-buthionine sulfoximine… CONTINUE READING

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